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Aldosterone and the RAAS Cascade

Renin to angiotensin II to aldosterone, regulating sodium, potassium, and blood pressure.

A free, animated aldosterone and the raas cascade you can read here or embed on any website, from Scrollchart.

Aldosterone and the RAAS Cascade

Aldosterone and the RAAS CascadeRenin to angiotensin II to aldosterone: blood pressure and sodium homeostasisTriggerLow BP · low Na+ · sympathetic toneMacula densa and JG baroreceptor sense itreninreninACE (lung)AT-II binds AT1RKidneyJG cells release reninAngiotensinogenliver substrateAngiotensin IdecapeptideAngiotensin IIoctapeptide · potentAdrenal cortexzona glomerulosaResultBP and intravascular volume restoredNa+ reabsorption at distal nephron · K+ excretedDrug targets: ACEi, ARBs, MRAs, renin inhibitorsPlasma aldosterone normal 50 to 280 pg/mL

Low blood pressure / low Na triggers renin release; renin cleaves angiotensinogen to AT-I; ACE converts to AT-II; AT-II stimulates aldosterone, which retains Na and water at the kidney.

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  • Articles in the health science category
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Source & accuracy

This aldosterone and the raas cascade is an editorial illustration built to represent the concept accurately. Where it shows figures, they are typical or representative values chosen to make the relationship clear, not a single underlying dataset. The diagram and its explainer are reviewed and maintained centrally, and updated over time as understanding improves.

Tracing the renin to aldosterone chain

The renin-angiotensin-aldosterone system links a drop in blood pressure or sodium to a hormonal correction. Juxtaglomerular cells in the kidney release renin when they sense low perfusion pressure, low filtered sodium at the macula densa, or sympathetic stimulation. Renin cleaves liver-made angiotensinogen into angiotensin I.

Angiotensin-converting enzyme, found mainly on the lung vasculature, then converts angiotensin I into angiotensin II, the active vasoconstrictor. Angiotensin II tightens blood vessels and prompts the adrenal cortex to secrete aldosterone, completing the cascade named in the diagram.

What aldosterone does to sodium and potassium

Aldosterone acts on the distal tubule and collecting duct of the nephron, increasing reabsorption of sodium and water while promoting potassium and hydrogen ion excretion. Holding onto sodium and water expands blood volume, which raises blood pressure back toward set point. This is why the system is described as a feedback loop rather than a one-way switch.

Because this pathway sets blood pressure and electrolyte balance, several common medications target it, including ACE inhibitors and aldosterone-receptor blockers. The interactions here are genuinely clinical. This is general educational information, not medical advice; medication and electrolyte decisions should be made with a qualified professional.

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Reference

What this is
A free, embeddable, animated aldosterone and the raas cascade for any website.
Who uses it
Medical educators, Health blogs, Patient-info sites.
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License
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