Skip to content
Scrollchart
Supplements Medium #apigenin#chamomile#gaba

Apigenin (Chamomile Flavonoid)

Apigenin binds GABA-A benzodiazepine site, also acts as a CD38 inhibitor for NAD+ preservation.

A free, animated apigenin (chamomile flavonoid) you can read here or embed on any website, from Scrollchart.

Apigenin (Chamomile Flavonoid)

Apigenin (Chamomile Flavonoid)One molecule, two pathways: GABA-A benzodiazepine-site binding for sleep, CD38 inhibition for NAD+Apigenin4 prime,5,7-trihydroxyflavonechamomile, parsley, celeryPath 1: Sleep and anxiety (dominant)Binds benzodiazepine allosteric site of GABA-A(alpha-gamma subunit interface)Partial agonist: lower intrinsic efficacy than diazepamNo sedation ceiling, minimal muscle relaxation at doseChamomile extract: 50 to 120 mg apigenin equivalentRoughly 50 percent anxiety reduction in one RCT (GAD)Path 2: CD38 inhibition (NAD+ longevity)CD38 (NAD+ glycohydrolase) normally consumes NAD+Apigenin inhibits CD38 in vitro (IC50 approx 13 uM)Cellular NAD+ pool maintainedDownstream: SIRT1 and SIRT3 activity sustainedMitochondrial efficiency improved (mouse data)Human translation uncertain at typical supplement dosesloworalbio-availDosing: sleep effect at 50 mg standardised chamomile. NAD+ effect speculative below 100 mg pure apigenin; higher doses raise plasma exposure.Sleep evidence: Mao 2016 GAD RCT, Amsterdam 2009 anxiety RCT.NAD+ evidence: Escande 2013 (mouse), human RCTs pending.

Apigenin binds the benzodiazepine site of GABA-A with low intrinsic activity, modestly enhancing inhibitory tone. A second pathway: CD38 inhibition slowing NAD+ degradation, popularized by longevity researchers.

Good for

  • Chamomile and sleep supplement explainers
  • NAD+ and longevity stack reviews
  • Anxiolytic flavonoid mechanism articles

Source & accuracy

This apigenin (chamomile flavonoid) is an editorial illustration built to represent the concept accurately. Where it shows figures, they are typical or representative values chosen to make the relationship clear, not a single underlying dataset. The diagram and its explainer are reviewed and maintained centrally, and updated over time as understanding improves.

Two distinct actions of the chamomile flavonoid

Apigenin is a flavonoid found in chamomile, parsley, and celery. It is studied for binding the benzodiazepine site on the GABA-A receptor, the same broad site targeted by anti-anxiety drugs, which is the proposed basis for its mild calming and sleep-supporting reputation, though its affinity is weak. Separately, apigenin can inhibit CD38, an enzyme that consumes NAD+, which is the rationale behind its inclusion in some longevity-oriented formulas aiming to preserve cellular NAD+.

These are two unrelated mechanisms that explain its appearance in both sleep and NAD+ products.

How firm the human evidence is

Most of the GABA and CD38 findings come from cell and animal studies, and chamomile's traditional calming use is suggestive rather than proof of a specific apigenin dose effect. Bioavailability of oral apigenin is also limited. The mechanisms are plausible but the clinical evidence in people is preliminary.

This is general educational information, not medical advice. Apigenin may interact with sedatives and other medications. Consult a qualified professional before use.

Embed this diagram

Add this animated apigenin (chamomile flavonoid) to your own site. Copy one line of HTML, or use the embed builder for theme and sizing options.

Reference

What this is
A free, embeddable, animated apigenin (chamomile flavonoid) for any website.
Who uses it
Supplement reviewers, Biohacker blogs, Wellness sites.
How to embed
Copy one line of HTML. No signup. No watermark. Works in WordPress, Webflow, Ghost, Substack, plain HTML.
File size
iframe embed, ~80 KB gzipped (loads on demand, does not block your page paint).
License
Free forever. Editorial explainer text included; updated centrally over time.
URL
scrollchart.com/diagram/apigenin-mechanism

Embed format options

Copy the universal HTML snippet, the WordPress shortcode, or an iframe fallback - see the WordPress plugin page for details. Any format keeps the same Core Web Vitals profile and the same explainer text.

Embed snippet 
<div data-scrollchart="apigenin-mechanism" data-scrollchart-v="1"></div>
<script src="https://scrollchart.com/embed.js" async></script>

By embedding, you acknowledge the diagram and explainer text are served from scrollchart.com and may be updated from time to time to reflect new research or to link to relevant sources within the explainer.

Frequently asked questions

Where can I get a free animated "Apigenin (Chamomile Flavonoid)" for my website?
Scrollchart provides "Apigenin (Chamomile Flavonoid)" as a free, embeddable animated diagram you can add to any website with one line of HTML. No signup is required and there is no watermark. The diagram and its explainer text are served from scrollchart.com, so the embed stays current without any maintenance on your end.
How do I embed a apigenin (chamomile flavonoid) diagram in a health or wellness blog?
Copy the HTML snippet from the Scrollchart diagram page and paste it into any post or page in your CMS. It works in WordPress, Webflow, Ghost, Substack, and plain HTML without any plugin or account. The diagram renders as animated SVG directly in your page, so search engines can index the accompanying explainer text.
Related diagrams

Other supplements explainers

See all supplements →
Supplements Medium

Valerian Root Mechanism

Valerenic acid binds GABA-A and inhibits GABA reuptake, raising synaptic GABA.
Supplements Medium

GABA-A Receptor Mechanism

The brain's primary inhibitory channel: chloride flows in, neurons quiet down.
Supplements Rich

Magnesium Glycinate Sleep Mechanism

Magnesium modulates NMDA and GABA-A receptors; the glycinate carrier doubles as an inhibitory neurotransmitter.