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Aquaporin Water Channels

AQP-2 tetramers pass 3 billion water molecules per second while the NPA selectivity filter blocks protons, ions, and all solutes larger than water.

A free, animated aquaporin water channels you can read here or embed on any website, from Scrollchart.

Aquaporin Water Channels

Aquaporin Water ChannelsAQP-2 tetramer passes water 100x faster than diffusion; NPA motif excludes protonsExtracellularIntracellularH+Proton excludedby NPA dipoleOsmotic driveHigh osmolaritydraws water INAQP-2: ADH-gatedThroughput3 billionH2O/channel/secvs ~30/sec by simplediffusion aloneKey isoformsAQP-1: RBC, kidneyAQP-2: renal tubuleAQP-4: astrocytesAQP-7: adipocytesSingle-file threading and the NPA electrostatic barrier block proton conduction while permitting 3 billion water molecules per channel per second

Lipid bilayer cross-section with AQP-2 tetramer embedded. Water molecules thread single-file through the central pore. NPA selectivity filter excludes protons via dipole electrostatics. Left panel: osmotic driving force and ADH-gated regulation. Right panel: throughput rate (3 billion H2O/channel/sec vs ~30 by simple diffusion). Isoform callout: AQP-1 (RBC, kidney), AQP-2 (renal collecting duct), AQP-4 (astrocytes), AQP-7 (adipocytes).

Good for

  • Kidney physiology and hydration regulation articles
  • ADH and diabetes insipidus patient education
  • Cell biology membrane transport course supplements

Source & accuracy

This aquaporin water channels is an editorial illustration built to represent the concept accurately. Where it shows figures, they are typical or representative values chosen to make the relationship clear, not a single underlying dataset. The diagram and its explainer are reviewed and maintained centrally, and updated over time as understanding improves.

How aquaporins move water so fast

Aquaporins are membrane proteins that form dedicated channels for water, letting it cross cell membranes far faster than it could by simple diffusion. They typically assemble as tetramers, with each of the four subunits forming its own narrow pore. Estimates of throughput are very high, on the order of billions of water molecules per channel per second, which is why aquaporins are central wherever the body moves water quickly, such as in the kidney.

AQP2 in the kidney is a well-studied example: hormonal signals from antidiuretic hormone move AQP2 channels into the membrane to reabsorb water and concentrate urine.

Why they pass water but block ions and protons

The channel is engineered for selectivity. A constriction point and a pair of conserved asparagine-proline-alanine (NPA) motifs reorient water molecules as they thread through single file, while the local electric field prevents the relay of protons that would otherwise hop along a water chain. The pore is also too narrow for hydrated ions and larger solutes.

This combination lets water flow freely while keeping out charged particles, preserving the cell's electrical and chemical gradients. This is general educational information about molecular biology.

Embed this diagram

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Reference

What this is
A free, embeddable, animated aquaporin water channels for any website.
Who uses it
Medical educators, Biology educators, Health blogs, Science popularizers.
How to embed
Copy one line of HTML. No signup. No watermark. Works in WordPress, Webflow, Ghost, Substack, plain HTML.
File size
iframe embed, ~80 KB gzipped (loads on demand, does not block your page paint).
License
Free forever. Editorial explainer text included; updated centrally over time.

Embed format options

Copy the universal HTML snippet, the WordPress shortcode, or an iframe fallback - see the WordPress plugin page for details. Any format keeps the same Core Web Vitals profile and the same explainer text.

Embed snippet
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Frequently asked questions

Where can I get a free animated "Aquaporin Water Channels" for my website?
Scrollchart provides "Aquaporin Water Channels" as a free, embeddable animated diagram you can add to any website with one line of HTML. No signup is required and there is no watermark. The diagram and its explainer text are served from scrollchart.com, so the embed stays current without any maintenance on your end.
How do I embed a aquaporin water channels diagram in a health or wellness blog?
Copy the HTML snippet from the Scrollchart diagram page and paste it into any post or page in your CMS. It works in WordPress, Webflow, Ghost, Substack, and plain HTML without any plugin or account. The diagram renders as animated SVG directly in your page, so search engines can index the accompanying explainer text.