One division versus two
Mitosis is a single division that produces two daughter cells genetically identical to the parent, each keeping the full chromosome number. It underlies growth, tissue maintenance, and repair throughout the body.
Meiosis is two consecutive divisions that start from one cell and yield four cells, each with half the chromosome number. It occurs only in the formation of gametes (eggs and sperm), so that fertilization restores the normal count.
Where the genetic shuffling happens
Meiosis generates variation in two ways absent from mitosis. During prophase I, paired homologous chromosomes exchange segments through crossover. Then independent assortment randomly distributes maternal and paternal chromosomes into the daughter cells.
A key structural difference is that homologous chromosomes pair up in meiosis I but never pair in mitosis. Errors in separating chromosomes during meiosis can produce gametes with the wrong number, which is the basis of conditions caused by an extra or missing chromosome.